期刊
LEUKEMIA & LYMPHOMA
卷 55, 期 10, 页码 2271-2276出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428194.2014.887711
关键词
Cyclophosphamide; prednisone; relapsed/refractory multiple myeloma; heart failure
资金
- Shanghai Health Bureau [20114327]
- Zhabei district Health Bureau [2011mxkg02]
Patients with relapsed/refractory (R/R) multiple myeloma (MM) complicated by severe heart failure typically do not tolerate conventional chemotherapy. Our previous study indicated that R/R MM patients with severe comorbidities could benefit from continuous low-dose oral cyclophosphamide and prednisone (CP regimen). We hereby performed a study of 56 R/R MM patients with severe heart failure (New York Heart Association class >= III) receiving the treatment of CP regimen. Among the 54 evaluable patients, clinical benefit was noted in 63.0% (complete response, 3.7%; very good partial response, 7.4%; partial response, 48.1%; stable disease, 3.7%). The median overall survival (OS) and progression-free survival (PFS) were 8 and 6 months. The left ventricular ejection fraction (LVEF) and the serum levels of B-type natriuretic peptide (BNP) were improved significantly. Slight adverse events were observed. In summary, the CP regimen is effective in R/R MM patients complicated with severe heart failure.
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