期刊
LEUKEMIA & LYMPHOMA
卷 56, 期 6, 页码 1636-1642出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428194.2014.951849
关键词
CD20; classical Hodgkin lymphoma; prognosis; immunohistochemistry; microenvironment
We studied by immunohistochemistry the background CD20 + cells in 131 cases of classical Hodgkin lymphoma (cHL). High CD20 + dispersed cells (CD20BG) showed a significant correlation with longer overall survival (OS) and a trend toward improved progression-free survival (PFS). At multivariate analysis high CD2OBG was also an independent prognostic factor of improved PFS and OS. The prognostic role of CD2OBG seems to be opposite with respect to tumor associated macrophages (TAMs) we studied previously in most cases of the series. We scored patients on the basis of the respective CD2OBG and TAM count and found that the combination of low CD2OBG and high TAMs was related to a significantly reduced PFS and OS at univariate and multivariate analysis. Microenvironment CD20 + cells seem to play a favorable prognostic role in cHL. Depletion of CD20 + cells together with an increase of TAMs identifies a group of patients with high-risk disease.
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