期刊
LEUKEMIA & LYMPHOMA
卷 54, 期 9, 页码 1989-1995出版社
INFORMA HEALTHCARE
DOI: 10.3109/10428194.2012.759656
关键词
Myeloproliferative neoplasm; polycythemia vera; young; JAK2 V617F; splanchnic vein thrombosis
The natural history and prognosis for young patients with polycythemia vera (PV) in the post-JAK2 V617F era are not well defined. Therefore, we retrospectively analyzed disease characteristics and clinical outcomes in 120 patients <= 45 years and 84 patients >= 65 years at diagnosis. Despite lower white blood counts (9.2 vs. 13.4 x 10(9)/L, p = 0.004) and a lower JAK2 V617F allele burden (51% vs. 66%, p = 0.015), younger patients with PV had comparable rates of vascular complications compared to older patients (27% vs. 31%, p = 0.64). However, splanchnic vein thrombosis occurred more frequently in younger patients (13% vs. 2%, p = 0.0056). Myelofibrotic and leukemic transformation, the most serious complications of myeloproliferative neoplasms (MPN), occurred with similar frequencies in young versus older patients (15% vs. 10%, p = 0.29). Prevention or delay of these complications is currently the most urgent challenge in the care of younger patients with PV.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据