相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation
Ramiro Paris et al.
CELL CYCLE (2008)
Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation
Mingxuan Xia et al.
CELL CYCLE (2008)
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
Sanieev Shangary et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
Sanjeev Shangary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia
Chris Saddler et al.
BLOOD (2008)
Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination
Linghu Nie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
Kensuke Kojima et al.
BLOOD (2006)
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
Ke Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
J-C Marine et al.
CELL DEATH AND DIFFERENTIATION (2006)
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to nutlin-3
JT Patton et al.
CANCER RESEARCH (2006)
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy
K Kojima et al.
BLOOD (2005)
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
GL Bond et al.
CELL (2004)
INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene
M Pinyol et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
分享论文
