期刊
LEUKEMIA & LYMPHOMA
卷 50, 期 10, 页码 1573-1580出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190903115410
关键词
TLR; B cells; chronic lymphocytic leukemia; lymphoma; myeloma
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- CLL Global Research Foundation and Ministero della Salute
- Progetto Integrato Oncologia
- Federazione Italiana per la Ricerca sul Cancro (FIRC)
Toll-like receptors (TLR) are key players in host defence from infection. They recognize a specific set of molecular patterns of microbial origin, immediately trigger an innate immune response, and bridge innate and adaptive immunity. TLR have also been shown to play a role in tumor development. In this context, chronic B-cell malignancies are an interesting example as clonal B lymphocytes remain responsive to and dependent on stimuli originating from the microenvironment which then become crucial for maintaining and propagating the disease. Emerging evidences suggest that, among other microenvironmental elements, TLR ligands may play a role in the pathogenesis of chronic B-cell lymphoid malignancies. Conceivably, their manipulation may find a place in specific settings of treatment of these tumors.
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