期刊
LEUKEMIA & LYMPHOMA
卷 50, 期 8, 页码 1261-1268出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190903026492
关键词
Chronic lymphocytic leukemia; cytopenia; autoimmune hemolytic anemia; immune thrombocytopenia; pure red blood cell aplasia
资金
- Mayo Clinic Hematological Malignancies Fund
- University of Iowa
- Mayo Clinic NIH SPORE [CA97274]
- Bayer Health Care Pharmaceuticals
- NATIONAL CANCER INSTITUTE [P50CA097274] Funding Source: NIH RePORTER
Improved medical care could have altered the clinical presentation and survival of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) complicated by autoimmune disease cytopenia (AID cytopenia). We reviewed the clinical characteristics, treatment, and outcome of AID cytopenia that was diagnosed in 75 (4.3%) of 1750 patients with CLL seen at a single institution over 10 years. When compared with the historical reported data, our study shows a lower rate of autoimmune hemolytic anemia (2.3%), and similar rates of immune thrombocytopenia (2.0%), and pure red blood cell aplasia (0.5%). AID cytopenia occurred at all stages of CLL, responded well to treatment, did not alter overall survival, and contributed to death in only 6 (12%) patients. We propose that more sensitive and accurate diagnostic methods for CLL have decreased the perceived prevalence of AID cytopenia and that improvements in management could have increased the survival of these patients.
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