期刊
LEUKEMIA & LYMPHOMA
卷 49, 期 12, 页码 2344-2350出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190802441347
关键词
Electromagnetic fields; gene-environment interactions; DNA damage; single nucleotide polymorphisms; cancer
资金
- Science and Technology Commission of Shanghai Municipality [07dz22013]
- Shanghai Key Laboratory of Children's Environmental Health [06DZ22024]
- Shanghai Municipal Education Commission [T0204, 08YZ41]
- Shanghai Municipal Bureau of Health, China [05III002]
A case-only study was conducted in 123 patients with sporadic acute leukemia (AL). The locations of electric transformers and power lines were noted in each area, and their distances from the houses of the study patients were measured. The intensities of magnetic fields (B) were measured in 66 cases. Unconditional logistic regression analysis was performed adjusting for age, gender, parental education and occupation, indoor and outdoor pesticides use, presence of television sets, refrigerators and microwave ovens in children's rooms and the presence of chemical factories or telecommunication transmitters within 500m of the houses. The results of the gene-environment analyses revealed that an interaction existed between the XRCC1 Ex9+16 A allele and the presence of electric transformers and power lines within 100m (Mean B=0.14Teslas,T) of the houses (interaction odds ratio, COR=4.31, 95%CI: 1.54-12.08). The COR for the interaction of XRCC1 Ex9+16A and the presence of these installations within 50m (Mean B=0.18T) of the houses was 4.39 (95%CI: 1.42-13.54). Our results suggest a possible association between electric transformers and power lines and the XRCC1 Ex9+16A allele in patients with childhood AL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据