期刊
LEUKEMIA
卷 26, 期 8, 页码 1862-1869出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2012.42
关键词
multiple myeloma; plasma cells; CD81; flow cytometry; phenotype; survival
资金
- Cooperative Research Thematic Network (RTICs) [RD06/0020/0006, RD06/0020/0005, RD06/0020/0031, RD06/0020/0101, RD06/0020/1056, RD06/0020/0041, G03/136]
- MM Jevitt
- SL firm
- Instituto de Salud Carlos III/Subdireccion General de Investigacion Sanitaria [FIS: PI060339, 06/1354, 02/0905, 01/0089/01-02, PS09/01897/01370]
- Consejeria de Sanidad, Junta de Castilla y Leon, Valladolid, Spain [557/A/10]
- Celgene
- Janssen-Cilag
The presence of CD19 in myelomatous plasma cells (MM-PCs) correlates with adverse prognosis in multiple myeloma (MM). Although CD19 expression is upregulated by CD81, this marker has been poorly investigated and its prognostic value in MM remains unknown. We have analyzed CD81 expression by multiparameter flow cytometry in MM-PCs from 230 MM patients at diagnosis included in the Grupo Espanol de Mieloma (GEM)05 > 65years trial as well as 56 high-risk smoldering MM (SMM). CD81 expression was detected in 45% (103/230) MM patients, and the detection of CD81(+) MM-PC was an independent prognostic factor for progression-free (hazard ratio = 1.9; P = 0.003) and overall survival (hazard ratio = 2.0; P = 0.02); this adverse impact was validated in an additional series of 325 transplant-candidate MM patients included in the GEM05 <65 years trial. Moreover, CD81(+) SMM (n = 34/56, 57%) patients had a shorter time to progression to MM (P = 0.02). Overall, our results show that CD81 may have a relevant role in MM pathogenesis and represent a novel adverse prognostic marker in myeloma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据