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The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4
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Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4•MLL fusion allele
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LEUKEMIA (2007)
Combined effects of the two reciprocal t(4; II) fusion proteins MLL . AF4 and AF4 . MLL confer resistance to apoptosis, cell cycling capacity and growth transformation
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Transcription linked to recombination:: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene
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ONCOGENE (2007)
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
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Controlling the elongation phase of transcription with P-TEFb
B. Matija Peterlin et al.
MOLECULAR CELL (2006)
A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy
Weili Chen et al.
BLOOD (2006)
A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology
M. Metzler et al.
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The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression
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Development of an autofluorescent translocation biosensor system to investigate protein-protein interactions in living cells
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ANALYTICAL CHEMISTRY (2005)
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Interaction of AF4 wild-type and AF4. MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?
A Bursen et al.
ONCOGENE (2004)
Taspase1:: A threonine aspartase required for cleavage of MLL and proper HOX gene expression
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CELL (2003)
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
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MOLECULAR AND CELLULAR BIOLOGY (2003)
Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties
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Systematic identification of novel protein domain families associated with nuclear functions
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GENOME RESEARCH (2002)
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