期刊
LEUKEMIA
卷 25, 期 2, 页码 211-217出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2010.248
关键词
stem cell mobilization; hematopoietic stem and progenitor cell; G-CSF; CXCL12; CXCR4; monocytes
资金
- NHLBI NIH HHS [R01 HL060772] Funding Source: Medline
Under normal conditions, the great majority of hematopoietic stem/progenitors cells (HSPCs) reside in the bone marrow. The number of HSPCs in the circulation can be markedly increased in response to a number of stimuli, including hematopoietic growth factors, myeloablative agents and environmental stresses such as infection. The ability to 'mobilize' HSPCs from the bone marrow to the blood has been exploited clinically to obtain HSPCs for stem cell transplantation and, more recently, to stimulate therapeutic angiogenesis at sites of tissue ischemia. Moreover, there is recent interest in the use of mobilizing agents to sensitize leukemia and other hematopoietic malignancies to cytotoxic agents. Key to optimizing clinical mobilizing regimens is an understanding of the fundamental mechanisms of HSPC mobilization. In this review, we discuss recent advances in our understanding of the mechanisms by which granulocyte colony-stimulating factor (G-CSF), the prototypical mobilizing agent, induces HSPC mobilization. Leukemia (2011) 25, 211-217; doi:10.1038/leu.2010.248; published online 16 November 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据