期刊
LETTERS IN ORGANIC CHEMISTRY
卷 7, 期 2, 页码 168-171出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017810790796318
关键词
Enzymatic synthesis; protease; dipeptides; ionic liquid
Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM. PF6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for biocatalysis.
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