期刊
LETTERS IN ORGANIC CHEMISTRY
卷 7, 期 2, 页码 163-167出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017810790796237
关键词
Mifepristone; estra-Delta(5(10),9(11))-diene; cinchona alkaloids; chiral ammonium salts
资金
- Xianju Zhiyao Erchang, Zhe Jiang Province, China
A modified phase-transfer catalysed enantioselective epoxidation of estra-Delta(5(10),9(11))-diene, an important intermediate of anti-early pregnancy drug mifepristone 1, have been determined and investigated. Eight chiral ammonium salts (PTC A-H), used as phase-transfer catalysts, have been synthesized from cinchona alkaloids. Among them, PTC G and PTC H have exhibited satisfying catalytic activity to improve the ratio of alpha/beta epoxide up to 7:1.
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