Synthesis of Pyrrolizidine Derivatives in Ionic Liquid [bmim] Br

Pyrrolizidines were synthesized from 1,3-dipolar cycloaddition of N-substituted isatins, proline, and olefins. The highly diastereoselective and regioselective one-pot three-component cyclocondensation products were obtained in the presence of ionic liquids such as 1-buthyl-3-methlylimidazolium bromide.