期刊
LETTERS IN ORGANIC CHEMISTRY
卷 5, 期 8, 页码 602-606出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017808786857499
关键词
Nitroalkenes; organocatalysts; solvent-free condition; Michael addition
资金
- The Ministero dell'Universita e della Ricerca (MIUR)
- Universita degli Studi di Perugia
- Merck's Chemistry Council
Under solvent-free condition the addition of dimethyl malonate ( 1) to (E)-beta-nitrostyrenes 2a-j proceeds smoothly in the presence of 2.5 mol% of 6'-hydroxy cinchonine (QD-OH) and equimolar amounts of reagents at 30 C. The corresponding products 3a-j are obtained with satisfactory enantiomeric excesses (68-88%) and high yields (70-92%).
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