期刊
LETTERS IN DRUG DESIGN & DISCOVERY
卷 7, 期 9, 页码 640-643出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018010792929540
关键词
Coumarin; Dihydropyrazole; Molecular Docking; Antitumor Agent
资金
- National Natural Science Foundation of China [20902003]
- University Natural Science, Anhui Province [KJ2009A011Z]
A series of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential telomerase inhibitors were synthesized. The bioassay tests showed that compound 3b exhibited potentially high activity against human gastric cancer cell SGC-7901 with IC50 value was 2.98 +/- 0.16. Docking simulation was performed to position compound 3b into the telomerase (3DU6) active site to determine the probable binding model. The result shows that some coumarin containing 4,5-dihydropyrazole moiety can combine well with the telomerase active site and may have use as potential telomerase inhibitors.
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