期刊
LETTERS IN APPLIED MICROBIOLOGY
卷 57, 期 6, 页码 467-475出版社
WILEY
DOI: 10.1111/lam.12134
关键词
biofilm; deoxyribonuclease; extracellular DNA; genetic transformation; nucleoprotein
资金
- Society for Applied Microbiology for investigations on eDNA in oral biofilms
The death and lysis of microbial cells leads to the release of cytoplasmic contents, many of which are rapidly degraded by enzymes. However, some macromolecules survive intact and find new functions in the extracellular environment. There is now strong evidence that DNA released from cells during lysis, or sometimes by active secretion, becomes a key component of the macromolecular scaffold in many different biofilms. Enzymatic degradation of extracellular DNA can weaken the biofilm structure and release microbial cells from the surface. Many bacteria produce extracellular deoxyribonuclease (DNase) enzymes that are apparently tightly regulated to avoid excessive degradation of the biofilm matrix. Interfering with these control mechanisms, or adding exogenous DNases, could prove a potent strategy for controlling biofilm growth.
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