期刊
LETTERS IN APPLIED MICROBIOLOGY
卷 52, 期 2, 页码 177-180出版社
WILEY
DOI: 10.1111/j.1472-765X.2010.02977.x
关键词
France; Francisella tularensis; holarctica; MLVA; SNP; VNTR
资金
- Department of Homeland Security (DHS) Science and Technology Directorate [NBCH2070001, HSHQDC-08-C-00158]
- Northern Arizona University
Aim: To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates. Methods and Results: Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates. We confirmed the presence of one subclade, the central and western European group (B.Br.FTNF002-00), and identified four major MLVA genotypes with no obvious geographical differentiation. Conclusions: The lack of geographical resolution among MLVA genotypes suggests rapid dispersal, convergent evolution or a combination of the two. Significance and Impact of the Study: This study expands knowledge of the phylogeography of one of the two dominant European F. tularensis ssp. holarctica subclades and illustrates the need for additional SNP discovery within this subclade.
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