期刊
LEARNING & MEMORY
卷 20, 期 12, 页码 710-729出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.026542.112
关键词
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资金
- New York Stem Cell Initiative [NYSTEM C026430]
- NIH [R37 MH068542]
- Hope for Depression Research Foundation
- Kavli Institute
- Gatsby
- Swartz
- Kavli Foundations
In the adult mammalian brain, newly generated neurons are continuously incorporated into two networks: interneurons born in the subventricular zone migrate to the olfactory bulb, whereas the dentate gyrus (DG) of the hippocampus integrates locally born principal neurons. That the rest of the mammalian brain loses significant neurogenic capacity after the perinatal period suggests that unique aspects of the structure and function of DG and olfactory bulb circuits allow them to benefit from the adult generation of neurons. In this review, we consider the distinctive features of the DG that may account for it being able to profit from this singular form of neural plasticity. Approaches to the problem of neuro-genesis are grouped as bottom-up, where the phenotype of adult-born granule cells is contrasted to that of mature developmentally born granule cells, and top-down, where the impact of altering the amount of neurogenesis on behavior is examined. We end by considering the primary implications of these two approaches and future directions.
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