期刊
QUIMICA NOVA
卷 38, 期 2, 页码 237-242出版社
SOC BRASILEIRA QUIMICA
DOI: 10.5935/0100-4042.20150001
关键词
Salacia crassifolia; Celastraceae; pentacyclic triterpenes; antimicrobial property
资金
- Fundacao de Amparo a pesquisa do Estado de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
The phytochemical study of hexane extract from leaves of Salacia crassifolia resulted in the isolation of 3 beta-palmitoxy-urs-12-ene, 3-oxofriedelane, 3 beta-hydroxyfriedelane, 3-oxo-28-hydroxyfriedelane, 3-oxo-29-hydroxyfriedelane, 28,29-dihydroxyfriedelan-3-one, 3,4-seco-friedelan-3-oic acid, 3 beta-hydroxy-olean-9(11):12-diene and the mixture of alpha-amirin and beta-amirin. beta-sitosterol, the polymer gutta-percha, squalene and eicosanoic acid were also isolated. The chemical structures of these constituents were established by IR, H-1 and C-13 NMR spectral data. Crude extracts and the triterpenes were tested against Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis and no activity was observed under the in vitro assay conditions. The hexane, chloroform, ethyl acetate and ethanol crude extracts, and the constituent 3,4-seco-friedelan-3-oic acid and 28,29-dihydroxyfriedelan-3-one showed in vitro antimicrobial activity against Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Streptococcus sanguinis and Candida albicans.
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