期刊
LEARNING & MEMORY
卷 16, 期 6, 页码 362-366出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.1365609
关键词
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资金
- National Institutes of Mental Health [F31 MH-067445]
- National Institutes of Health [R37 AG-08796, T32 AG20506]
Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits were exposed in a subset (30%) of middle-aged mice that performed below criterion on a hippocampal-dependent contextual fear conditioning task. Basal neuronal excitability was comparable in middle-aged and young mice, but learning-related modulation of the post-burst afterhyperpolarization (AHP)-a general mechanism engaged during learning-was impaired in CA1 neurons from middle-aged weak learners. Thus, modulation of neuronal excitability is critical for retention of context fear in middle-aged mice. Disruption of AHP plasticity may contribute to contextual fear deficits in middle-aged mice-a model of age-associated cognitive decline (AACD).
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