期刊
LASERS IN SURGERY AND MEDICINE
卷 40, 期 8, 页码 584-589出版社
WILEY
DOI: 10.1002/lsm.20674
关键词
epidermal growth factor receptor (EGFR); gold nanoshells; hypericin; photodynamic therapy (PDT); photothermal therapy (PTT)
资金
- Singapore Bioimaging Consortium
- A*STAR
- Division of Bioengineering, National University of Singapore
Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm(2) and compare their cell viability using crystal fast violet assay. Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.
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