期刊
LASER PHYSICS LETTERS
卷 11, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1612-2011/11/1/015602
关键词
cerebrospinal fluid; Raman spectroscopy; meningitis
资金
- Russian Foundation for Basic Research [12-02-00672-a]
- Government of the Russian Federation (Grant of the Government of the Russian Federation for the Support of Scientific Investigations under Supervision of Leading Scientists) [14.B25.31.0019]
In this work, the spatial localization of leucocytes, bacteria, and erythrocytes in the crystal pattern of a dried droplet of cerebrospinal fluid (CSF) is established. Characteristic lines are detected and identified in the Raman spectrum of the CSF that point to the presence of pathologic cells therein and can be used in a timely way to diagnose meningitis, the spectroscopic sample preparation procedure being simple enough. A dry CSF sample retains its characteristic spectral features for no less than three days, which is important for its safe keeping and transportation, and also for the computer processing of its spectra.
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