期刊
LASER PHYSICS LETTERS
卷 6, 期 1, 页码 76-79出版社
IOP PUBLISHING LTD
DOI: 10.1002/lapl.200810092
关键词
antioxidative potential; in vivo Raman microspectroscopy; carotinoids; topical application; stratum corneum
资金
- Foundation Skin Physiology of the Donor Association for German Science and Humanities
In the present study, the distribution of the carotenoids as a marker for the complete antioxidative potential in human skin was investigated before and after the topical application of carotenoids by in vivo Raman spectroscopy with an excitation wavelength of 785 nm. The carotenoid profile was assessed after a short term topical application in 4 healthy volunteers. In the untreated skin, the highest concentration of natural carotenoids was detected in different layers of the stratum corneum (SC) close to the skin surface. After topical application of carotenoids, an increase in the antioxidative potential in the skin could be observed. Topically applied carotenoids penetrate deep into the epidermis down to approximately 24 mu m. This study supports the hypothesis that antioxidative substance are secreted via eccrine sweat glands and/or sebaceous glands to the skin surface. Subsequently they penetrate into the different layers of the SC.
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