期刊
LASER & PHOTONICS REVIEWS
卷 7, 期 5, 页码 698-731出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/lpor.201200049
关键词
Fiber optic probe; endoscopy; Raman spectroscopy; coherent anti-Stokes Raman; surface-enhanced Raman spectroscopy; clinical diagnostics
This review focuses on fiber optic probes for linear and nonlinear Raman spectroscopy, especially for medical applications. It aims at providing an overview over contemporary technology, recent first clinical trials, and helps identifying future developments necessary to bring the emerging technology to clinical end users. After a short introduction to linear and nonlinear Raman spectroscopic modalities, general design considerations will be discussed and compared to common fiber probe setups. Subsequently, examples for medical applications of fiber optic Raman probes will be given concentrating on probes for linear Raman spectroscopy as these devices are technologically more mature compared to their counterparts based on nonlinear Raman spectroscopy. The review also includes a brief summary of first multimodal fiber optic probes and highlights their benefits for clinical applications. Finally, probes are introduced which employ either nonlinear Raman spectroscopy or surface enhanced spectroscopy.
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