期刊
LARYNGOSCOPE
卷 123, 期 12, 页码 3233-3238出版社
WILEY-BLACKWELL
DOI: 10.1002/lary.24236
关键词
Sleep; reflux; gastroesophageal reflux; GERD; OSA; apnea; insomnia; hypersomnia; laryngopharyngeal reflux; extraesophageal reflux; nose; nasal obstruction; anxiety; depression; mood; sleep disorders; heartburn; sleep medicine; pepsin; Western blot immunoassay; insomnia; quality of life
资金
- Inspire Medical
Objectives/HypothesisGastroesophageal reflux disease and heartburn negatively impact sleep; the impact of extraesophageal reflux (EER) symptoms on sleep is unknown. This study's goal was to evaluate the association of EER and measures of nasal obstruction, mood, insomnia, hypersomnia, and obstructive sleep apnea (OSA) risk. Study DesignCross-sectional study. SettingTertiary care hospital. Subjects and MethodsA prospective cohort of adult patients was evaluated using validated questionnaires for insomnia (PSQI), hypersomnia (ESS), OSA risk (STOP-Bang), sleep quality of life (FOSQ-10), EER reflux symptoms (RSI), nasal symptoms (NOSE), and measures of mood (HADA). Pharyngeal saliva samples underwent Western blot immunoassay for pepsin. ResultsNinety-three adults (mean age 50.215.2 years, 43% female) were evaluated. Reflux Symptom Index (RSI) was elevated in 32% of patients and significant heartburn symptoms were reported in only 12% of patients. Prevalence of pepsin (+) was 27%. Both RSI and NOSE were significantly associated with sleep measures related to insomnia (r=0.48 and r=0.50; P<0.001, respectively), Quality of Life (QOL) (r=0.30 and r=0.34; P<0.001, respectively), and hypersomnolance (r=0.18 and P<0.04; r=0.29 and P<0.01, respectively), but not apnea risk (all P<0.05). Nasal symptoms and mood were associated with all non-OSA sleep metrics (r=0.24). In multivariate analysis, both NOSE and RSI remained significantly associated with sleep measures. ConclusionsInsomnia, hypersomnia, and sleep QOL are associated with measures of EER, nasal symptoms, and mood but not OSA risk, supporting that disrupted sleep may be associated with EER and nasal symptoms independent of sleep apnea. Level of Evidence4. Laryngoscope, 123:3233-3238, 2013
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据