期刊
LARYNGOSCOPE
卷 121, 期 6, 页码 1212-1218出版社
WILEY
DOI: 10.1002/lary.21788
关键词
Depression; quality of life; dysphagia; voice handicap index; head and neck cancer
Objectives: To determine the incidence of depression in head and neck cancer (HNCA) patients and the effect of depression on baseline head-and neck-specific measures of quality of life and function. Study Design: Prospective cohort analysis. Methods: A total of 255 patients were prospectively evaluated using the Beck Depression Inventory Fast-Screen (BDI-FS) survey, University of Washington Quality of Life (UW QOL), Voice Handicap Index (VHI), and MD Anderson Dysphagia Inventory (MDADI) questionnaires. Patients with a preexisting diagnosis of depression were excluded. Results: Complete data were available for 77 patients with HNCA and 53 controls. Depressive symptoms were identified in 9% of controls and 19% of HNCA patients, and were significantly associated with a HNCA diagnosis (OR = 4.1, P = .044). Among patients with HNCA, depression was significantly more common in black patients (OR = 15.8, P = .017). A significant negative correlation was found between BDI-FS score and UW global QOL score (r = -0.4, P = .0019). Depression was significantly associated with poorer UW global QOL (beta = -22.46, P = .0004), recreation (beta = -13.77, P = .037), speech (beta = -24.05, P = .004), and MDADI functional (beta = -17.31, P = .009), physical (beta = -14.99, P = .032), and emotional (beta = -11.60, P = .049) domain scores but not with other UW QOL or VHI domains, after controlling for all other variables. Conclusions: Patients with HNCA have a high incidence of depressive symptoms at diagnosis, which is significantly higher in black patients, and is associated with poorer QOL and MDADI scores. Pretreatment depression may serve as a marker for patients with increased risk of swallowing impairment and reduced QOL who would benefit from targeted intervention.
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