期刊
QUARTERLY REVIEWS OF BIOPHYSICS
卷 48, 期 4, 页码 389-394出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033583515000049
关键词
Combinatorial Libraries; Pleiotropism; Cell Fates Regulations
类别
资金
- JBP foundation
- Zebra Biologics Inc.
To date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.
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