期刊
LANGMUIR
卷 30, 期 9, 页码 2522-2529出版社
AMER CHEMICAL SOC
DOI: 10.1021/la404941m
关键词
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资金
- National Science Foundation [CBET 1264470]
- Defense Advanced Research Projects Agency [DARPA N66001-12-1-4263]
- NSF
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1264470] Funding Source: National Science Foundation
A photo-cross-linkable carboxybetaine (CB)-terminated thiol with only one CB headgroup was introduced to modify gold nanoparticles (GNPs) via self-assembled monolayers (SAMs). This CB-terminated thiol consists of three moieties: (a) an anchoring thiol group, which binds directly to the GNP surface, (b) a CB terminal group, which is highly resistant to protein adsorption, and (c) a diacetylene group in the middle, which is converted to a poly(enyne) structure during UV irradiation via 1,4-topochemical polymerization. Results show that, after cross-linking, CB-modified GNPs are highly resistant to protein adsorption from undiluted human blood serum and cell uptake, and are stable at low pH and high temperature. This cross-linkable CB thiol holds tremendous potentials for biomedical applications where stable and thin coatings are needed.
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