期刊
LANGMUIR
卷 30, 期 10, 页码 2820-2827出版社
AMER CHEMICAL SOC
DOI: 10.1021/la4025926
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资金
- Deutsche Forschungsgemeinschaft [WI 3637/1-1]
- Helmholtz Association
Their capability to change their shape on demand has created significant interest for shape-memory polymers (SMPs) in minimally invasive surgery. To evaluate the miniaturization of SMP matrices for small-sized implants or controlled release systems, a strategy to prepare and evaluate microsized SMP model particles is required. This methodological study reports the emulsion-based preparation of similar to 30 mu m microparticles (MPs) from a phase-segregated SMP, poly(epsilon-caprolactone) [PCL] and poly(omega-pentadecalactone) [PPDL], with a particular focus on the effects of process parameters such as polymer solvents or stabilizer type/concentration on formation and size distribution of SMP MPs. Processes for the preparation of SMP MP-loaded water-soluble polymer films with tailored mechanical properties were developed and applied for programming the SMP MP to a temporary ellipsoid shape by film stretching. For the functional evaluation of shape recovery of MPs, a light microscopy-based setup with temperature control is proposed by which the stimuli-induced switching of the microsized SMP matrices could be confirmed. Overall, by applying this methodological strategy to various thermoplastic SMPs, a routine to identify and characterize the microscale functionality of SMPs in miniaturized applications will be broadly accessible.
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