期刊
LANGMUIR
卷 29, 期 32, 页码 10254-10263出版社
AMER CHEMICAL SOC
DOI: 10.1021/la401929v
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资金
- DBT, New Delhi (CEIB project) [BT/01/CEIB/V/13]
- CSIR, New Delhi (CSIR grant) [09/080(0776)/2011-EMR-1]
- DBT under the CEIB program in the Department of Organic Chemistry, IACS, Kolkata
A well-known nonsteroidal anti-inflammatory drug (NSAID), namely, naproxen (Np), was conjugated with beta-alanine and various combinations of amino alcohols and L-alanine. Quite a few bioconjugates, thus synthesized, were capable of gelling pure water, NaCl solution (0.9 wt %), and phosphate-buffered saline (PBS) (pH 7.4). The hydrogels were characterized by rheology and electron microscopy. Hydrogelation was probed by FT-IR and temperature-variable H-1 NMR studies. Single-crystal X-ray diffraction (SXRD) of a nonhydrogelator and a hydrogelator in the series established a useful structure-property (gelation) correlation. MTT assay of the hydrogelators in the mouse macrophage RAW 264.7 cell line showed excellent biocompatibility. The prostaglandin E-2 (PGE(2)) assay of the hydrogelators revealed their anti-inflammatory response, which was comparable to that of the parent NSAID naproxen sodium (Ns).
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