期刊
APPLIED SURFACE SCIENCE
卷 336, 期 -, 页码 188-195出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2014.10.177
关键词
MAPLE; Kanamycin; Anti-biofilm; Functionalized nanoparticles; Magnetite; Thin films
类别
资金
- Sectorial Operational Programme Human Resources Development of the Ministry of European Funds [POSDRU/159/1.5/S/132397]
- EU [1877, CNRS 49154]
In this study we aimed to evaluate the biocompatibility and antimicrobial activity of kanamycin functionalized 5 nm-magnetite (Fe3O(4)@ KAN) nanoparticles thin films deposited by Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. A laser deposition regime was established in order to stoichiometrically transfer Fe3O4@ KAN thin films on silicone and glass substrates. Morphological and physico-chemical properties of powders and coatings were characterized by XRD, TEM, SEM, AFM and IR microscopy(IRM). Our nanostructured thin films have proved efficiency in the prevention of microbial adhesion and mature biofilms development as a result of antibiotic release in its active form. Furthermore, kanamycin functionalized nanostructures exhibit a good biocompatibility, both in vivo and in vitro, demonstrating their potential for implants application. This is the first study reporting the assessment of the in vivo biocompatibility of a magnetite-antimicrobial thin films produced by MAPLE technique. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据