期刊
LANGMUIR
卷 29, 期 12, 页码 4092-4095出版社
AMER CHEMICAL SOC
DOI: 10.1021/la304075c
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资金
- excellence initiative of the German Federal Government [EXC 294]
- excellence initiative of the German State Government [EXC 294]
- fifth INTERREG Upper Rhine Program [A21: NANO@MATRIX]
- University of Freiburg
When polymeric nanoparticles (NPs) are formed by nanoprecipitation, which is a nucleation-growth process, the control over size requires changing the polymer concentration or solvent composition. Here, we demonstrate that the NP size can be controlled independent of polymer variables by introducing a polyelectrolyte (PE) in the aqueous phase. PEs that exhibit hydrogen bonding (H-bonding) yield a reduction in NP size, whereas PEs that do not possess this characteristic promote the formation of larger NPs. The observed effect can be attributed to the formation of a diffusional barrier around the NP in the form of a dense shell. This principle of controlling NP size is not limited to polymers and can also be employed in the production of lipid NPs.
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