期刊
LANGMUIR
卷 28, 期 31, 页码 11599-11608出版社
AMER CHEMICAL SOC
DOI: 10.1021/la302210b
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资金
- EPSRC [EP/F048114/1, EP/G026203/1]
- [SC3235]
- [20110562]
- BBSRC [BB/I008187/1] Funding Source: UKRI
- EPSRC [EP/F048114/1, EP/G026203/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I008187/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/F048114/1, EP/G026203/1] Funding Source: researchfish
The self-assembly of the peptide amphiphile (PA) hexadecyl-(beta-alanine-histidine) is examined in aqueous solution, along with its mixtures with multilamellar vesicles formed by DPPC (dipalmitoyl phosphatidylcholine). This PA, denoted C-16-beta AH, contains a dipeptide headgroup corresponding to the bioactive molecule L-carnosine. It is found to self-assemble into nanotapes based on stacked layers of molecules. Bilayers are found to coexist with monolayers in which the PA molecules pack with alternating up down arrangement so that the headgroups decorate both surfaces. The bilayers become dehydrated as PA concentration increases and the number of layers in the stack decreases to produce ultrathin nanotapes comprised of 2-3 bilayers. Addition of the PA to DPPC multilamellar vesicles leads to a transition to well-defined unilamellar vesicles. The unique ability to modulate the stacking of this PA as a function of concentration, combined with its ability to induce a multilamellar to unilamellar thinning of DPPC vesicles, may be useful in biomaterials applications where the presentation of the peptide function at the surface of self-assembled nanostructures is crucial.
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