期刊
LANGMUIR
卷 28, 期 38, 页码 13550-13554出版社
AMER CHEMICAL SOC
DOI: 10.1021/la302550q
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资金
- CNRS
- INSERM
- University of Strasbourg
- Region Alsace
- Agence Nationale de la Recherche through the Programme Blanc [ANR-10-BLAN-0818]
- Agence Nationale de la Recherche (ANR) [ANR-10-BLAN-0818] Funding Source: Agence Nationale de la Recherche (ANR)
The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation of the film. This strategy is successfully applied for the release in solution of an anticancer drug initially loaded within the architecture.
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