期刊
LANGMUIR
卷 27, 期 7, 页码 4020-4028出版社
AMER CHEMICAL SOC
DOI: 10.1021/la104825u
关键词
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资金
- 2010-initiative start-up fund
- Center for the Research and Development of Light-Activated Materials (CRDLM)
- [NSF-CHE-0722632]
- [NSF-EPS-0903804]
- [NSF- CHE-0840507]
- [DOE-DE-EE0000270]
- EPSCoR
- Office Of The Director [0903804] Funding Source: National Science Foundation
The antibacterial properties of zinc oxide nanoparticles were investigated using both Gram-positive and Gram-negative microorganisms. These studies demonstrate that ZnO nanoparticles have a wide range of antibacterial activities toward various microorganisms that are commonly found in environmental settings. The antibacterial activity of the ZnO nanoparticles was inversely proportional to the size of the nanoparticles in S. aureus. Surprisingly, the antibacterial activity did not require specific UV activation using artificial lamps, rather activation was achieved under ambient lighting conditions. Northern analyses of various reactive oxygen species (ROS) specific genes and confocal microscopy suggest that the antibacterial activity of ZnO nanoparticles might involve both the production of reactive oxygen species and the accumulation of nanoparticles in the cytoplasm or on the outer membranes. Overall, the experimental results suggest that ZnO nanoparticles could be developed as antibacterial agents against a wide range of microorganisms to control and prevent the spreading and persistence of bacterial infections.
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