期刊
LANGMUIR
卷 27, 期 21, 页码 12891-12901出版社
AMER CHEMICAL SOC
DOI: 10.1021/la202990y
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资金
- National Research Agency (ANR) [ANR-06-TecSan-015-03, ANR-07-BLAN-0290-01]
- European Commission [CP-IP 213631-2 NANOTHER]
- Agence Nationale de la Recherche (ANR) [ANR-07-BLAN-0290] Funding Source: Agence Nationale de la Recherche (ANR)
The physical adsorption of PEOn-b-PLLm copolymers onto silica nanoparticles and the related properties of poly(ethylene oxide) (PEO)-coated particles were studied as a function of the block copolymer composition. Copolymers adopt an anchor buoy conformation at the particle surface owing to a preferential affinity of poly(L-lysine) (PLL) blocks with the silica surface over PEO blocks when a large excess of copolymer is used. The interdistance between PEO chains at particle surface is highly dependent on the size of PLL segments; a dense brush of PEO is obtained for short PLL blocks (DP = 10), whereas PEO chains adopt a so-called interacting mushroom conformation for large PLL blocks (DP = 270). The size of the PEO blocks does not really influence the copolymer surface density, but it has a strong effect on the PEO layer thickness as expected. Salt and protein stability studies led to similar conclusions about the effectiveness of a PEO layer with a dense brush conformation to prevent colloidal aggregation and protein adsorption. Besides, a minimal PEO length is required to get full stabilization properties; as a matter of fact, both PEO45-b-PLL10 and PEO113-b-PLL10 give rise to a PEO brush conformation but only the latter copolymer efficiently stabilizes the particles in the presence of salt or proteins.
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