期刊
LANGMUIR
卷 25, 期 2, 页码 1086-1090出版社
AMER CHEMICAL SOC
DOI: 10.1021/la803288s
关键词
-
资金
- Australian Microscopy and Microanalysis Research Facitity (AMMRF)
- Flinders University
Drug-membrane interactions assume considerable importance in pharmacokinetics and drug metabolism. Here, we present the interaction of chlorpromazine hydrochloride (CPZ) with supported phospholipid bilayers. It was demonstrated that CPZ binds rapidly to phospholipid bilayers, disturbing the molecular ordering of the phospholipids. These interactions were observed to follow first order kinetics, with an activation energy of similar to 420 kJ mol(-1). Time-dependent membrane disruption was also observed for the interaction with CPZ, such that holes appeared in the phospholipid bilayer after the interaction of CPZ. For this process of membrane disruption, lag-burst kinetics was demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据