期刊
LANGMUIR
卷 24, 期 20, 页码 11866-11871出版社
AMER CHEMICAL SOC
DOI: 10.1021/la802048s
关键词
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资金
- National Natural Science Foundation of China [90713024]
- National Basic Research Program of China [2007CB935601]
- Chinese Academy of Sciences
Conjugation of the cell-penetrating peptide derived from the human immunodeficiency virus-1 transactivator protein (TAT) to semiconductor quantum dots (QDs) is an effective way to enhance transmembrane delivery of QDs for intracellular and molecular imaging. In this work, the internalization pathway of TAT-QDs was studied systematically in living cells. Cellular uptake of TAT-QDs, under different endocytosis-inhibiting conditions, was compared by fluorescence imaging and flow cytometry. The results suggest TAT-QDs internalize through lipid-raft-dependent macropinocytosis, which is different from that of FITC-labeled TAT. They also provide new information for better understanding of the TAT-mediated cell uptake mechanism.
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