期刊
LANCET ONCOLOGY
卷 13, 期 4, 页码 385-394出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1470-2045(11)70404-1
关键词
-
类别
资金
- Ovarian Cancer Research Fund
- National Institutes of Health [R01 CA136891, CA14089, CA17054, CA61132, N01 PC67010, R03 CA113148, R01 CA112523, R01 CA87538, R01 CA58598, N01 CN67001, N01 PC35137, 5R01 CA074850, R01 CA76016, CA58860, CA92044, PSA 042205, R01 CA54419, P50 CA105009, R01 CA61107, R01 CA95023, R01 CA126841, R01 CA122443, P50 CA136393]
- California Cancer Research Program [0001389V20170, 2110200]
- California Department of Health Services [050E8709]
- Lon V Smith Foundation [LVS 39420]
- European Community [HEALTH-F2-2009-223175]
- German Federal Ministry of Education and Research of Germany [01GB9401]
- German Cancer Research Centre
- Eve Appeal
- Oak Foundation
- University College London Hospital/University College London Comprehensive Biomedical Research Centre
- National Health and Medical Research Council of Australia [199600]
- US Army Medical Research and Materiel Command [DAMD 170110729, W81XWH0610220, W81XWH1010280, DAMD17-02-1-0669]
- Cancer Council Tasmania
- Cancer Foundation of Western Australia
- Mermaid 1
- Danish Cancer Society
- Roswell Park Alliance Foundation
- U.S. Department of Defense (DOD) [W81XWH1010280, W81XWH0610220] Funding Source: U.S. Department of Defense (DOD)
Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an international collaborative study to assess the association between endometriosis and histological subtypes of ovarian cancer. Methods Data from 13 ovarian cancer case-control studies, which were part of the Ovarian Cancer Association Consortium, were pooled and logistic regression analyses were undertaken to assess the association between self-reported endometriosis and risk of ovarian cancer. Analyses of invasive cases were done with respect to histological subtypes, grade, and stage, and analyses of borderline tumours by histological subtype. Age, ethnic origin, study site, parity, and duration of oral contraceptive use were included in all analytical models. Findings 13 226 controls and 7911 women with invasive ovarian cancer were included in this analysis. 818 and 738, respectively, reported a history of endometriosis. 1907 women with borderline ovarian cancer were also included in the analysis, and 168 of these reported a history of endometriosis. Self-reported endometriosis was associated with a significantly increased risk of clear-cell (136 [20 . 2%] of 674 cases vs 818 [6 . 2%] of 13 226 controls, odds ratio 3 . 05, 95% CI 2 . 43-3 . 84, p<0 . 0001), low-grade serous (31 [9 . 2%] of 336 cases, 2 . 11, 1 . 39-3 . 20, p<0 . 0001), and endometrioid invasive ovarian cancers (169 [13 . 9%] of 1220 cases, 2 . 04, 1 . 67-2 . 48, p<0 . 0001). No association was noted between endometriosis and risk of mucinous (31 [6 . 0%] of 516 cases, 1 . 02, 0 . 69-1 . 50, p=0 . 93) or high-grade serous invasive ovarian cancer (261 [7 . 1%] of 3659 cases, 1 . 13, 0 . 97-1 . 32, p=0 . 13), or borderline tumours of either subtype (serous 103 [9 . 0%] of 1140 cases, 1 . 20, 0 . 95-1 . 52, p=0 . 12, and mucinous 65 [8 . 5%] of 767 cases, 1 . 12, 0 . 84-1 . 48, p=0 . 45). Interpretation Clinicians should be aware of the increased risk of specific subtypes of ovarian cancer in women with endometriosis. Future efforts should focus on understanding the mechanisms that might lead to malignant transformation of endometriosis so as to help identify subsets of women at increased risk of ovarian cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据