期刊
LANCET NEUROLOGY
卷 17, 期 10, 页码 905-917出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(18)30287-4
关键词
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资金
- Medical Research Council [SNCF G1002055, MR/P012418/1, ERA-NET NEURON MR/R005532/1, MR/M501785/1]
- International Spinal Research Trust [TR1004_01, NRB113]
- Rosetrees Trust [JS16/M276]
- International Foundation for Research in Paraplegia [P165F]
- National Institutes of Health, National Institute of Child Health and Human Development [R01 HD079009-02]
- National Institute on Disability, Independent Living, and Rehabilitation Research [90SI5016-01-00]
- Department of Defense Congressionally Directed Medical Research Programs [SCIRP W81XWH-16-1-0395]
- Wellcome Trust [097903/Z/11/Z, 102645/Z/13/Z]
- Nevro Corporation
- International Spinal Research Trust [NRB113] Funding Source: researchfish
- Medical Research Council [MR/P012418/1, MR/M501785/1] Funding Source: researchfish
- Rosetrees Trust [M276-F1] Funding Source: researchfish
- Wellcome Trust [097903/Z/11/Z, 102645/Z/13/Z] Funding Source: researchfish
- Wellcome Trust [097903/Z/11/Z] Funding Source: Wellcome Trust
Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as a treatment approach in several neurological disorders, including deep brain stimulation for Parkinson's disease and epidural spinal stimulation for chronic pain. Neuromodulation can also be beneficial for spinal cord injury, from assisting basic functions such as respiratory pacing and bladder control, through to restoring volitional movements and skilled hand function. Approaches range from electrical stimulation of peripheral muscles, either directly or via brain-controlled bypass devices, to stimulation of the spinal cord and brain. Limitations to widespread clinical application include durability of neuromodulation devices, affordability and accessibility of some approaches, and poor understanding of the underlying mechanisms. Efforts to overcome these challenges through advances in technology, together with pragmatic knowledge gained from clinical trials and basic research, could lead to personalised neuromodulatory interventions to meet the specific needs of individuals with spinal cord injury.
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