期刊
LANCET NEUROLOGY
卷 13, 期 6, 页码 614-629出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(14)70090-0
关键词
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资金
- Roche and Pfizer
- Boehringer lngelheim
- Bristol-Myers Squibb
- Elan Corporation
- Wyeth
- Novartis
- Pfizer
- Schwabe
- Sanofi-Aventis
- Eisai
- Roche Pharmaceuticals and Diagnostics
- GE Healthcare
- AstraZeneca
- Avid
- Eli Lilly and Company
- Janssen-Cilag
- Merz Pharmaceuticals
- GlaxoSmithKline Biologicals
- Jung Diagnostics
- Thermo Fisher Scientific Clinical Diagnostics BRAHM S GmbH
- Novartis and Nutricia
- Janssen
- Lundbedc
- Sanofi
- research and clinical trials from Eli Lilly
- GE Healthcare and Bayer Health.
- Avid Radiopharmaceuticals
- Bayer/Piramal
- Avid Radiopharmaceuticals,
- Janssen Alzheimer's Immunotherapy
- Baxter
- Genetech
- Roche
- Merck
- Biogen
- Genentech
- Johnson Johnson
- Eli Lilly
- GE Healthcare for an investigator-initiated study
- Alzheimers Research UK [ARUK-SRF2013-8] Funding Source: researchfish
- Economic and Social Research Council [ES/L001810/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10134, NF-SI-0508-10123] Funding Source: researchfish
- ESRC [ES/L001810/1] Funding Source: UKRI
In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fiuorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the predinical states of AD.
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