期刊
LANCET NEUROLOGY
卷 13, 期 9, 页码 913-923出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(14)70085-7
关键词
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资金
- EU [211696]
- NIH/NIAID [U01 318345]
- Swedish Research Council [523-2005-8460]
- State University of New York Research Foundation
Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body-mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood brain barrier integrity, and risk of all-cause late-onset dementia and Alzheimer's disease. This observation leads us to question what it is about body-mass index that is associated with health of the brain and dementia risk. If high body-mass index and central adiposity represent an increase in adipose tissue, then the endocrine function of adipose tissue, mediated by adipose tissue hormones and adipokines, could be a due to mechanisms that underlie the association with dementia and Alzheimer's disease. Hundreds of adipoldnes have been identified, creating a complexity that is a challenge to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, and with imaging-based measures of brain volume, structure, and function in human beings and in predinical models of clinical dementia.
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