期刊
LANCET NEUROLOGY
卷 11, 期 3, 页码 272-282出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(11)70307-6
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资金
- Alberta Innovates Health Solutions
- Alberta Heritage Fund for Medical Research
- Canadian Institutes of Health Research
- Scottish Funding Council
- National Institutes of Health for the study of microinfarcts in cerebral amyloid angiopathy [2R01 AG26484-01]
- Medical Research Council [G0700704B] Funding Source: researchfish
The association between small but still visible lacunar infarcts and cognitive decline has been established by population-based radiological and pathological studies. Microscopic examination of brain sections shows even smaller but substantially more numerous microinfarcts, the focus of this Review. These lesions often result from small vessel pathologies such as arteriolosclerosis or cerebral amyloid angiopathy. They typically go undetected in clinical radiological correlation studies that rely on conventional structural MRI, although the largest acute microinfarcts can be detected by diffusion-weighted imaging. In view of their high numbers and widespread distribution, microinfarcts could directly disrupt important cognitive networks and thus account for some of the neurological dysfunction associated with lesions visible on conventional MRI such as lacunar infarcts and white matter hyperintensities. Standardised neuropathological assessment criteria and the development of non-invasive means of detection during life would be major steps towards understanding the causes and consequences of otherwise macroscopically invisible microinfarcts.
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