期刊
LANCET NEUROLOGY
卷 9, 期 6, 页码 623-633出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1474-4422(10)70112-5
关键词
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资金
- National Institute Aging [AG 16573]
- Generalitat de Catalunya [2009SGR1313]
- Spanish Ministry of Science and Technology [SAF2007-60827, SAF2007-31093-E]
- Fondo de Investigacion Sanitaria [PI 082038]
- Marato TV3 [062230]
- Jerome Lejeune Foundation [JMLM/AC/08-044]
- Areces Foundation
- Reina Sofia Foundation
- European Union [LSHG-CT-2006-037627, EU/FIS PS09102673]
Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity. Diagnosis and treatment of neurological complications are important in maintaining optimal cognitive functioning. The cognitive phenotype in Down's syndrome is characterised by impairments in morphosyntax, verbal short-term memory, and explicit long-term memory. However, visuospatial short-term memory, associative learning, and implicit long-term memory functions are preserved. Seizures are associated with cognitive decline and seem to cause additional decline in cognitive functioning, particularly in people with Down's syndrome and comorbid disorders such as autism. Vision and hearing disorders as well as hypothyroidism can negatively impact cognitive functioning in people with Down's syndrome. Dementia that resembles Alzheimer's disease is common in adults with Down's syndrome. Early-onset dementia in adults with Down's syndrome does not seem to be associated with atherosclerotic complications.
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