期刊
LANCET INFECTIOUS DISEASES
卷 14, 期 8, 页码 751-762出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1473-3099(14)70710-8
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资金
- National Institutes of Health [R01-AI100135-01]
- Bill & Melinda Gates Foundation Global Health [OPPGH5284, OPP1035192]
- National Health and Medical Research Council of Australia Career Development Fellowship [572504]
- Swedish Medical Research Council [VR K2009-54X-21119-01-4, VR2012-2992]
- VINNMER-Marie Curie international qualification (VINNOVA) [2011-03458]
- Bill & Melinda Gates Foundation-Grand Challenges Explorations [OPP1036135]
- government grant in Public Health Service at the Sahlgrenska University Hospital [ALFGBG-142881]
- European Union grant FP7 (Neurobid) [HEALTHF2-2009-241778]
- Leducq foundation [DSRR_P34404]
- Ahlen Foundation
- Swedish Brain Foundation [FO2013-095]
- Doris Duke Charitable Foundation
- National Institutes of Health
- Bill and Melinda Gates Foundation [OPP1036135] Funding Source: Bill and Melinda Gates Foundation
Preterm birth and infectious diseases are the most common causes of neonatal and early childhood deaths worldwide. The rates of preterm birth have increased over recent decades and account for 11% of all births worldwide. Preterm infants are at significant risk of severe infection in early life and throughout childhood. Bacteraemia, inflammation, or both during the neonatal period in preterm infants is associated with adverse outcomes, induding death, chronic lung disease, and neurodevelopmental impairment. Recent studies suggest that bacteraemia could trigger cerebral injury even without penetration of viable bacteria into the CNS. Here we review available evidence that supports the concept of a strong association between bacteraemia, inflammation, and cerebral injury in preterm infants, with an emphasis on the underlying biological mechanisms, clinical correlates, and translational opportunities.
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