期刊
LANCET
卷 384, 期 9952, 页码 1455-1465出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(14)60687-5
关键词
-
资金
- Medical Research Council
- UK National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre (NIHR SRMRC)
- National Institute for Health and Care Excellence (NICE)
- NIHR SRMRC
- National Institute on Ageing [NIH AG018859]
- MRC [MR/K00414X/1] Funding Source: UKRI
- Alberta Innovates [201200844] Funding Source: researchfish
- Medical Research Council [MR/K00414X/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10008] Funding Source: researchfish
Improvements in the control of haemorrhage after trauma have resulted in the survival of many people who would otherwise have died from the initial loss of blood. However, the danger is not over once bleeding has been arrested and blood pressure restored. Two-thirds of patients who die following major trauma now do so as a result of causes other than exsanguination. Trauma evokes a systemic reaction that includes an acute, non-specific, immune response associated, paradoxically, with reduced resistance to infection. The result is damage to multiple organs caused by the initial cascade of inflammation aggravated by subsequent sepsis to which the body has become susceptible. This Series examines the biological mechanisms and clinical implications of the cascade of events caused by large-scale trauma that leads to multiorgan failure and death, despite the stemming of blood loss. Furthermore, the stark and robust epidemiological finding-namely, that age has a profound influence on the chances of surviving trauma irrespective of the nature and severity of the injury-will be explored. Advances in our understanding of the inflammatory response to trauma, the impact of ageing on this response, and how this information has led to new and emerging treatments aimed at combating immune dysregulation and reduced immunity after injury will also be discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据