期刊
LANCET
卷 382, 期 9902, 页码 1433-1444出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(12)62163-1
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资金
- Wellcome Trust
- Kelly Group
- Medical Research Council
- Medical Research Council [G0902288, MR/J006742/1] Funding Source: researchfish
- MRC [G0902288] Funding Source: UKRI
Autoimmune hepatitis is a disease of the hepatic parenchyma that can present in acute or chronic forms. In common with many autoimmune diseases, autoimmune hepatitis is associated with non-organ-specific antibodies in the context of hepatic autoimmunity. This dichotomy has made definition of a unifying hypothesis in the pathophysiology of the disease difficult, although data from the past 8 years have drawn attention to the role of regulatory T cells. Several triggers have been identified, and the disease arises in genetically susceptible individuals. Clinical and biochemical remission is achievable in up to 85% of cases. For the remaining patients, alternative immunosuppression strategies are an option. Liver transplantation provides an excellent outcome for patients with acute liver failure or complications of end-stage liver disease, including hepatocellular carcinoma. Variant or overlapping syndromes are worthy of consideration when unexpected disease features arise.
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