期刊
PUBLIC HEALTH NUTRITION
卷 18, 期 18, 页码 3355-3370出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1368980015000646
关键词
Serum lipids; Colorectal adenoma; Colorectal cancer; TAG; Meta-analysis
资金
- National Natural Science Foundation of China [81302110, 81200263]
Objective: There have been inconsistent results published regarding the relationship between dyslipidaemia and an increased risk of colorectal neoplasia (CRN), including colorectal adenoma (CRA) and colorectal cancer (CRC). We conducted a meta-analysis to explore the relationship between dyslipidaemia and CRN. Design: We identified studies by performing a literature search using PubMed, EMBASE and the Science Citation Index through October 2013. Setting: We analysed thirty-three independent studies reporting the association between CRN and at least one of the selected lipid components, including total cholesterol (TC), TAG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C). Subjects: CRN cases (n 21 809) were identified. Results: Overall, people with high levels of serum TAG (risk ratio (RR)=1.08; 95 % CI 1.05, 1.12, P<0.00001) and LDL-C (RR=1.07; 95 % CI 1.00, 1.14, P=0.04) presented an increased prevalence of CRN. Subgroup analyses revealed that high levels of serum TC (RR=1.04; 95 % CI 1.01, 1.09, P=0.02), TAG (RR=1.06; 95 % CI 1.03, 1.10, P=0.0009) and LDL-C (RR=1.11; 95 % CI 1.04, 1.19, P=0.003) increased the risk of CRA but not of CRC. No association between serum HDL-C and risk for CRN (including CRA and CRC) was observed. Conclusions: Both TAG and LDL-C were significantly associated with an increasing prevalence of CRN. High levels of serum TC, TAG and LDL-C were positively associated with CRA but not with CRC. No significant association was observed between levels of serum HDL-C and CRN.
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