期刊
PUBLIC HEALTH GENOMICS
卷 18, 期 4, 页码 242-247出版社
KARGER
DOI: 10.1159/000433518
关键词
Genomics; Translational research; Genomic medicine; Next-generation sequencing; Genetic testing; Family health history; Global health
资金
- National Human Genome Research Institute, NIH, in the Center for Research on Genomics and Global Health (CRGGH)
- National Institute of Diabetes and Digestive and Kidney Diseases
- Center for Information Technology
- NIH [1ZIAHG200362]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [ZIAHG200362] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [P20MD006899] Funding Source: NIH RePORTER
Translation of genomic discoveries into patient care is slowly becoming a reality in developed economies around the world. In contrast, low- and middle-income countries (LMIC) have participated minimally in genomic research for several reasons including the lack of coherent national policies, the limited number of well-trained genomic scientists, poor research infrastructure, and local economic and cultural challenges. Recent initiatives such as the Human Heredity and Health in Africa (H3Africa), the Qatar Genonne Project, and the Mexico National Institute of Genomic Medicine (INMEGEN) that aim to address these problems through capacity building and empowerment of local researchers have sparked a paradigm shift. In this short communication, we describe experiences of small-scale medical genetics and translational genomic research programs in LMIC. The lessons drawn from these programs drive home the importance of addressing resource, policy, and sociocultural dynamics to realize the promise of precision medicine driven by genomic science globally. By echoing lessons from a bench-to-community translational genomic research, we advocate that large-scale genomic research projects can be successfully linked with health care programs. To harness the benefits of genomics-led health care, LMIC governments should begin to develop national genomics policies that will address human and technology capacity development within the context of their national economic and sociocultural uniqueness. These policies should encourage international collaboration and promote the link between the public health program and genomics researchers. Finally, we highlight the potential catalytic roles of the global community to foster translational genomics in LMIC. 2015 S.Karger AG, Basel
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