期刊
LAB ON A CHIP
卷 14, 期 11, 页码 1806-1810出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00199k
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资金
- EPSRC [EP/F500424/1, EP/I017887/1, EP/K038885/1]
- EPSRC fellowship [EP/K027611/1]
- Royal Academy of Engineering/EPSRC Fellowship
- Glasgow University Lord Kelvin and Adam Smith Research Fellowship
- EPSRC [EP/K027611/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I017887/1, EP/K038885/1, EP/K027611/1] Funding Source: researchfish
The key roles played by phospholipids in many cellular processes, has led to the development of model systems, to explore both lipid-lipid and lipid-peptide interactions. Biomimetic giant unilamellar vesicles represent close facsimiles of in vivo cellular membranes, although currently their widespread use in research is hindered by difficulties involving their integration into high-throughput techniques, for exploring membrane biology intensively in situ. This paper presents an integrated microfluidic device for the production, manipulation and high-throughput analysis of giant unilamellar vesicles. Its utility is demonstrated by exploring the lipid interaction dynamics of the pore-forming antimicrobial peptide melittin, assessed through the release of fluorescent dyes from within biomimetic vesicles, with membrane compositions similar to mammalian plasma membranes.
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